Medicine: Clinical precision

Precision medicine, technologies, and molecular diagnostics

Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...

Precision Chemistry for Precision Medicine

During the 2015 State of the Union address, President Obama unveiled plans for a $215 million Precision Medicine Initiative. The details of this plan were laid out by past and present directors of the National Institutes of Health, Harold Varmus and Francis Collins, in a commentary in the New England Journal of Medicine. While the announcement stood as a public statement of support for funding,...

Precision Medicine

Precision Medicine — Too Much Precision , Not Enough Medicine ?

he problem is that human biology and disease are far too complex to ever be described with total precision. The same is true for that most precise of the sciences, physics. I doubt that we will ever completely understand the real world. Only God is supposed to be able to do that. Human knowledge is fractal: the more you know about any subject, the more questions arise. That’s why the best scien...

Clinical tumor sequencing: opportunities and challenges for precision cancer medicine.

Advances in tumor genome sequencing have enabled discovery of actionable alterations leading to novel therapies. Currently, there are approved targeted therapies across various tumors that can be matched to genomic alterations, such as point mutations, gene amplification, and translocations. Tools to detect these genomic alterations have emerged as a result of decreasing costs and improved thro...